Ultra-Fast and Quantitation are not two terms that normally co-exist in the same sentence but in a new Application Note published by SCIEX, a method combining a Thermal Extraction Ionization Source (TEIS) from Mass Spec Analytical coupled with a SCIEX X500R QTOF system is used to establish a rapid screening method with minimal sample clean-up and no chromatography. The method for cocaine quantification resulted in real-time analysis times of only a few seconds per injection.
SCIEX X500R system is an easy to use, rugged and versatile instrument, ideal fit for screening and confirmation applications. When combined with the TEIS, the results shown in the application note suggest that quantitation using the Thermal Extraction Ionisation Source coupled with a SCIEX X500R for forensic applications is feasible without chromatography or sample preparation, with very fast acquisition times. This technique would afford a higher laboratory throughput and reduced consumable needs when compared to LC-MS approaches.
The application note can be viewed here.