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Compatible with liquids, solids and gases
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No sample preparation – source integrity preserved
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Compatible with Sciex Turbo-V mass spectrometers
The TEIS-XL is a standalone technique - it provides a rapid ionisation technique without LC for quick identification of compounds. The key benefit of the approach is the lack of sample preparation needed – meaning that a wide variety of methods can be accommodated.
TEIS-XL simply interfaces with Sciex mass spectrometers in the exact same way as an Electrospray Ionization (ESI) or Atmospheric Pressure Chemical Ionization (APCI) probe does.
The TEIS-XL Ion Source uses Mass Spec's proven sample introduction device: a heated nickel-anodised volatilisation chamber where ambient air is continuously drawn into this space and through a ceramic transfer line into the Atmospheric Pressure Chemical Ionisation (APCI) ion source. Compounds amenable to thermal desorption may be rapidly analysed in this way without the need for any sample pre-treatment, solvents or glassware.
The source is easy to use, reliable, and uses few or no consumables. The TEIS-XL can liberate samples from a large surface area, up to 120mm wide. Coupled with the specificity afforded by a tandem mass spectrometer, the TEIS-XL can provide real time results to a forensic standard. To make designing your solution easier, Mass Spec supports several different sample introduction methods including direct analysis from liquid direct injection from an autosampler or syringe, direct analysis from sampling materials, or from vapour.
The main difference between the TEIS-XL source and a chromatographic injection, is the time it takes for the ions to be detected in the mass spectrometer. Using TEIS-XL, the injection is detected within about 1-2 seconds (in real-time), via a direct injection without any separation. The TEIS-XL source enables rapid identification of compounds within a solid, liquid or vapour within seconds. Chromatography would require separation and sample clean-up, extending the method time to at best, a few minutes.
Mass Spec Analytical has demonstrated that compounds amenable to thermal desorption, such as many pesticides, drugs, and explosives, can be rapidly analysed in this way without the need for any sample pre-treatment, solvents, or glassware. Other applications such as drugs in sweat, oral fluids, dried blood spot testing and more have also been demonstrated; it is a very versatile ionisation source that could provide a rapid screening solution for many application areas.
The Thermal Extraction Ion Source significantly speeds up workflow times by a minimum of 30% or more for processes where GCMS is normally used for analysis. Much of the time saved is in the sample queue for analysis, which may be overnight, but there are other savings: no solvents, no glassware, no labelling of vials, no loading up the auto-sampler, no reconciling the queue with the sample list, no reconciling the results to the correct vial in the correct position, no GC columns, no special gases. An added benefit is that the lab would be able to give virtually instantaneous results to their clients or colleagues once the analysis is complete.
Download the TEIS Product Sheet