The paper, entitled ‘Rapid identification of seized controlled substances and related compounds by tandem mass spectrometry without chromatography,’ reveals how two chromatography-free techniques were used to screen for a large suite of compounds using a rapid, inexpensive technique: a thermal desorber coupled to a tandem mass spectrometer operated in selected reaction monitoring (SRM) mode. Solutions were introduced via autosampler, whilst powdered solid materials were directly analysed by dipping a toothpick into the powder and inserting this into the thermal desorber. The results were compared with those obtained by gas chromatography/mass spectrometry (GC/MS).
MS/MS was shown to be capable of the identification of the same drugs within the samples as the conventional method of GC/MS, but with better sensitivity and shorter analysis times. By eliminating chromatography, a higher laboratory throughput is achievable with simplified sample preparation.
The technique could be further validated with reference to an increasing database of MS/MS spectra to help to identify an expanding suite of compounds.
The paper, published in Rapid Communications in Mass Spectrometry, 15 April 2016 is authored by CM Fletcher, Department of Physical Sciences, University of Kent at Canterbury, Canterbury, Kent, CT2 7NZ, UK, and R Sleeman, Mass Spec Analytical Ltd, Building 20F, Golf Course Lane, Filton, Bristol, BS34 7RP, UK.
You can read more about thermal desorption here.